Gastric retention drug delivery systems can be retained in stomach for a long time such retention systems are important for drugs that are degraded in intestine or for drugs like antacids or certain antibiotics, enzymes that should act locally in the stomach such systems are more advantageous in improving GI absorption of drug with narrow absorption windows as well as for controlling release of drugs having site specific absorption limitation. Retention of drug delivery system in the stomach prolongs overall GI transit time, there by resulting in improved bioavailability for some drug. Present investigation highlights the formulation and optimization of floating tablet of ofloxacin.Ofloxacin is the first generation fluroquinolone. The plasma half-life of drug is approximately 4-5 Hrs. In present investigation three different viscosity grades of HPMC namely HPMC K4M, HPMC K15M, HPMC K100M were used in different concentrations. Tablet was formulated as a floating tablet using gas-generating agent Sodium bicarbonate. Formulation was optimized on the basis of floating time and in vitro drug release. Dissolution profile were subjected various kinetic drug release equation. The tablet were subjected to evaluation for physical characteristics like weight variation, hardness, friability, drug content uniformity, floating lag time, floating time and in vitro drug release. Formulation containing HPMC K100M (F9) showed desired duration of floating time (10hrs.) and drug release at the end of 10 hrs. Hence, it is evident from this investigation that gas powered floating tablet could be promising drug delivery system for ofloxacin and improved drug availability.
Loading....